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KMID : 0043320070300010028
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Archives of Pharmacal Research
2007 Volume.30 No. 1 p.28 ~ p.33
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Cytotoxic Constituents Isolated from the Fruit Bodies of Hypsizigus marmoreus
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Xu Ming-Lu
Choi Jae-Young
Jeong Byeong-Seon
Li Gao
Lee Kap-Rang
Lee Chong-Soon
Woo Mi-Hee
Lee Eung-Seok
Jahng Yurng-Dong
Chang Hyun-Wook
Lee Seung-Ho
Son Jong-Keun
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Abstract
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The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol (1), ergosterol-3-O-β-D-glucopyranoside (2), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), hypsiziprenol A9 (4), hypsiziprenol AA8 (5), hypsiziprenol AA9 (6) and hypsiziprenol BA10 (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.
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KEYWORD
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Hypsizigus marmoreus, cytotoxicity
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